Table 2.

Assessment criteria for the Biomarker Roadmap

Fully achieved	Available scientific evidence successfully replicated in properly powered and well-designed studies. Methodologically sound and well-powered studies have provided convincing evidence that has been replicated
Partly achieved	The available evidence is not sufficiently replicated, or samples are not adequately powered, or studies are faulted with major methodological limitations
Preliminary evidence	Only preliminary evidence is available
Not achieved	Studies are not yet performed at the time of the review
Unsuccessful	Available scientific evidence shows a failure for the biomarker in achieving the aim. Findings in the subsequent roadmap phases should be interpreted with caution