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. 2021 Jun;79(6):736–746. doi: 10.1016/j.eururo.2021.01.017

Fig. 2.

Fig. 2

Transcriptome analyses associating CD38 mRNA expression with immunoregulatory signalling pathway transcripts. (A and B) Unbiased transcriptome analyses of RNA-sequencing data from 159 patient biopsies in the SU2C/PCF mCRPC cohort for the association between CD38 and 200 PID signalling pathways. Red dots indicate immune signalling pathways and green dots nonimmunoregulatory pathways. CD38 was most significantly associated with the expression of multiple immune signalling pathway genes, and the ten most significant associations are shown (B). SU2C/PCF mCRPC transcriptome analyses of RNA-sequencing data from 159 patient biopsies for associations between CD38 and (C) a 14-gene adenosine signature, (D) an 18-gene adenosine signature, genes associated with CD8+ T cell exhaustion, (F) progenitor exhausted CD8+ T cell signature, and (G) terminally exhausted CD8+ T cell signature. The p values were calculated using linear regression analysis. mCRPC = metastatic castration-resistant prostate cancer; SU2C/PCF = International Stand Up To Cancer/Prostate Cancer Foundation.