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. 2021 Jun 3;4:674. doi: 10.1038/s42003-021-02199-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a O6-mFc chimeric protein screened on CFG mammalian glycan microarray at 10 µg/mL reveals the binding motif of O6 is (3 S)Galβ1-4GlcNAc. RFU relative fluorescence units, error bars = ±1 SD. b Monomeric VLR O6 binds to ligand with ~10 µM affinity. c No detectable binding curves were observed by ITC for the following structures: Galβ1-4GlcNAc, (3 S)Galβ1-3GlcNAc, (6 S)Galβ1-4GlcNAc and (3 S)Galβ1-4(Fucα1-3)GlcNAcβ-Sp. Yellow circle = Gal, yellow square = GalNAc, blue square = GlcNAc, red triangle = fucose, 3 S and 6 S = position of sulfate.