Fig. 7.

Schematic diagram of TAS2R138 involved lipid droplet degradation pathway. During P. aeruginosa infection, TAS2R138 competitively conjugated with PPARG antagonist AHL-12. The released PPARG redistributes from nuclear to cytoplasm to accelerate LDs degradation via binding with PLIN2. TAS2R138 binding with AHL-12 is associated with LDs, which is degraded during infection, thus helped the clearance of AHL-12 in neutrophils and promoting cell survival