Fig. 3.

Consequences of Sar1b mutation and deletion on biochemical parameters. Wild-type, Sar1b^mut/+, and Sar1b^del/+ female and male mice (9–11 weeks) were fed ad libitum with a conventional chow diet for 1 week. Before the sacrifice, mice were fasted for 6 h, followed by the recovery of 50 μl of blood from the tail vein. Fasting plasma (A) glucose, (B) insulin, (C) triglycerides, (D) total cholesterol, and (E) HDL-cholesterol concentrations were determined as described in the Materials and Method section. F: Non-HDL-cholesterol was also calculated. Results represent the means ± SEM of 10–13 mice in each group. ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001 versus wild-type mice (Ctrl).