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. 2021 Jun 3;11:11695. doi: 10.1038/s41598-021-91203-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Spheroid culture of iPSC derived motor neuron progenitors accelerates transcription of developmental and mature mRNAs. (a) Motor neuron progenitors cultured as 3D spheroids for 7, 14 and 21 days positive for Olig-2, HB-9, SMI-32 and Tuj-1. (b) Motor neuron progenitor cells cultured in monolayer for 2, 7, 14 and 21 days positive for SMI-32. (c) mRNA gene expression for neuronal stem cell marker PAX6, (d) progenitor marker OLIG2, (e) motor neuron marker ISLET1, (f) mature motor neuron marker SMI32 and (g) proliferative marker MKI67. Blue bars = Monolayer (2D), Red bars = Spheroid (3D). Data presented ± standard deviation (SD). *P ≤ 0.05, **P ≤ 0.01, and ***P ≤ 0.001. Scale bars = 200 µm.