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. 2021 Jun 3;11:11808. doi: 10.1038/s41598-021-91245-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Acute phase protocol. Following an initial sham smoking session, subjects were randomised to either a heat-not-burn or traditional cigarette smoking session; following a washout period of 60 min, they were crossed-over to the alternative smoking session. Each session was followed by a vascular stiffness examination and blood-sampling for oxidative stress and platelet activation assessment. Exam examination, HNBC heat-not-burn cigarette, TCig tobacco cigarette.