Table 2.
Comparative acute effects of heat-not-burn cigarettes versus tobacco cigarette on arterial stiffness, oxidative stress, platelet activation, and exposure to CO in the acute study (n = 50).
| Baseline | Sham | HNBC | TCig | |
|---|---|---|---|---|
| PWV (m/s) | 9.7 ± 1.3 | 9.9 ± 1.7 | 10.2 ± 1.7† | 10.8 ± 2.4*† |
| cSBP (mmHg) | 121 ± 16 | 120 ± 15 | 119 ± 17.6 | 120 ± 17 |
| Heart rate (bpm) | 66 ± 9 | 66 ± 9 | 66 ± 8 | 70 ± 10*† |
| SBP (mmHg) | 125 ± 15 | 125 ± 16 | 128 ± 19 | 130 ± 19*† |
| DBP (mmHg) | 79 ± 10 | 78 ± 10 | 80 ± 11 | 82 ± 10 |
| MDA (nmol/l) | 1.34 ± 0.72 | 1.35 ± 0.83 | 1.28 ± 0.95 | 2.56 ± 0.85*† |
| PC (nmol/mg protein) | 15.7 ± 5.8 | 14.5 ± 4.9 | 12.8 ± 5.2 | 13.9 ± 5.6 |
| TxB2 (ng/ml) | 378 ± 103 | 375 ± 105 | 362 ± 113 | 398 ± 105*† |
| CO (ppm) | 14.9 ± 7.4 | 14.4 ± 3.8 | 14.1 ± 7.3 | 17.5 ± 7.8*† |
*p < 0.05 of the overall model by ANOVA for the within subject effects of the tobacco products.
†p < 0.05 for the comparison of variables between baseline and after use of tobacco products by post hoc analysis using Bonferroni correction.
PWV carotid-femoral pulse wave velocity, CO carbon monoxide, HNBC heat-not-burn cigarette, MDA malondialdehyde, TCig tobacco cigarette, TxB2 thromboxane B2, values are mean±SD.