Table 3:
Spearman r and P-value for correlations between quantitative functional and structural scores with outcomes including the yearly change in FEV1 and number of pulmonary exacerbations for the year following the same-day assessment.
| Cohort | ΔFEV1 | # Pulmonary Exacerbations | |
|---|---|---|---|
| FEV1 z-score | All | r = −0.18 (P = 0.38) | r = −0.23 (P = 0.25) |
| Modulator | r = −0.36 (P = 0.20) | r = −0.16 (P = 0.59) | |
| No Modulator | r = 0.10 (P = 0.74) | r = −0.42 (P = 0.18) | |
| FEF25–75 z-score | All | r = −0.21 (P = 0.30) | r = −0.21 (P = 0.30) |
| Modulator | r = −0.36 (P = 0.20) | r = −0.26 (P = 0.38) | |
| No Modulator | r = 0.04 (P = 0.91) | r = −0.25 (P = 0.44) | |
| FEV1/FVC z-score | All | r = −0.08 (P = 0.68) | r = −0.13 (P = 0.51) |
| Modulator | r = −0.20 (P = 0.48) | r = −0.27 (P = 0.34) | |
| No Modulator | r = 0.12 (P = 0.71) | r = −0.02 (P = 0.96) | |
| LCI2.5 | All | r = 0.12 (P = 0.57) | r = 0.19 (P = 0.36) |
| Modulator | r = 0.46 (P = 0.09) | r = 0.04 (P = 0.89) | |
| No Modulator | r = −0.34 (P = 0.29) | r = 0.35 (P = 0.26) | |
| VDP | All | r = −0.39 (P = 0.05*) | r = 0.28 (P = 0.17) |
| Modulator | r = −0.44 (P = 0.12) | r = 0.27 (P = 0.34) | |
| No Modulator | r = −0.44 (P = 0.15) | r = 0.35 (P = 0.26) | |
| Total Brody Score | All | r = −0.03 (P = 0.90) | r = 0.30 (P = 0.13) |
| Modulator | r = 0.25 (P = 0.39) | r = 0.57 (P = 0.03*) | |
| No Modulator | r = −0.33 (P = 0.30) | r = 0.06 (P = 0.85) | |
| Mucus Plugging | All | r = −0.10 (P = 0.61) | r = 0.08 (P = 0.70) |
| Modulator | r = 0.35 (P = 0.23) | r = 0.15 (P = 0.60) | |
| No Modulator | r = −0.42 (P = 0.17) | r = 0.15(P = 0.63) | |
| Bronchial Wall Thickening | All | r = −0.12 (P = 0.56) | r = 0.39 (P = 0.05*) |
| Modulator | r = 0.10 (P = 0.74) | r = 0.71 (P < 0.01) | |
| No Modulator | r = −0.31 (P = 0.33) | r = 0.08 (P = 0.79) | |
| Bronchiectasis | All | r = −0.17 (P = 0.40) | r = 0.34 (P = 0.09) |
| Modulator | r = 0.08 (P = 0.80) | r = 0.65 (P = 0.01) | |
| No Modulator | r = −0.44 (P = 0.15) | r = 0.06 (P = 0.85) | |
| Ground Glass | All | r = 0.34 (P = 0.09) | r = 0.24 (P = 0.25) |
| Modulator | r = 0.46 (P = 0.10) | r = 0.23 (P = 0.44) | |
| No Modulator | r = 0.32 (P = 0.32) | r = 0.32 (P = 0.31) | |
| Consolidation/Atelectasis | All | r = 0.07 (P = 0.73) | r = 0.15 (P = 0.46) |
| Modulator | r = 0.17 (P = 0.57) | r = 0.11 (P = 0.71) | |
| No Modulator | r = −0.18 (P = 0.57) | r = 0.20 (P = 0.52) | |
| Air Trapping | All | r = 0.06 (P = 0.75) | r = −0.31 (P = 0.13) |
| Modulator | r = 0.23 (P = 0.43) | r = −0.21 (P = 0.46) | |
| No Modulator | r = −0.29 (P = 0.36) | r = −0.42 (P = 0.17) | |
| Cysts/Bullae | All | r = 0.01 (P = 0.95) | r = 0.35 (P = 0.08) |
| Modulator | r = −0.03 (P = 0.91) | r = 0.44 (P = 0.12) | |
| No Modulator | N/A* | N/A* |
Statistics are given for the entire cohort, those who started a modulator therapy the following year (n=14), and those who did not (n=12). Statistically significant correlations are in bold.
*
indicates no longer significant after correction for multiple tests.
*
N/A indicates inability to calculate due to all subjects having the same value (0, not present).