Summary of findings 2. Chinese herbal medicine (CHM) plus clomiphene versus clomiphene for subfertile women with PCOS.
| CHM plus clomiphene compared to clomiphene for subfertile women with PCOS | ||||||
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Population: subfertile women with PCOS Setting: fertility clinics Intervention: Chinese herbal medicine (CHM) + clomiphene Comparison: clomiphene | ||||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | Number of participants (studies) | Certainty of the evidence (GRADE) | Comments | |
| Assumed risk | Corresponding risk | |||||
| Clomiphene | CHM + clomiphene | |||||
| Live birth | Not reported | |||||
| Pregnancy rate (per woman) | 315 per 1000 | 584 per 1000 (485 to 677) | OR 3.06 (2.05 to 4.55) | 470 (6 RCTs) | ⊕⊕⊝⊝ lowa,b | |
| Adverse events | Not reported | |||||
| *The basis for the assumed risk is the median control group risk across studies. The corresponding risk (and its 95% CI) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). Abbreviations: CI: confidence interval; OR: odds ratio. | ||||||
| GRADE Working Group grades of evidence High certainty: we are very confident that the true effect lies close to that of the estimate of the effect. Moderate certainty: we are moderately confident in the effect estimate; the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Low certainty: our confidence in the effect estimate is limited; the true effect may be substantially different from the estimate of the effect. Very low certainty: we have very little confidence in the effect estimate; the true effect is likely to be substantially different from the estimate of effect. | ||||||
aDowngraded one level for serious risk of bias: study methods not described in sufficient detail. bDowngraded one level for serious imprecision: small studies, low overall event rate.