1. Contents of the formulations used in included studies.

Study	Type of intervention	Formula
Liang 2008	Bushen Huoxue formula	Basic formula: tu si zi 20 g, shu di 10 g, sang ji sheng 20 g, xian ling pi 15 g, bu gu zhi 10 g, huang jing 10 g, zao jiao ci 15 g, tao ren 10 g, shan ci gu 10 g, dan shen 10 g, gan cao 6 g plus huang qi 20 g, shan zha 10 g, fa ban xia 10 g in obese patients plus zhi mu 10 g, huang qin 10 g in hirsutism or acne patients
Li 2007	CHM preparations	Shenqi capsule: tu si zi 15 g, dang shen 20 g, ji xue teng 20 g, fu ling 15 g, dang gui 9 g, dan shen 15 g Ling zhu infusion: yin yang huo 9 g, xian mao 9 g, dan nan xing 9 g, bai zhu 15 g, dang gui 9 g, fa ban xia 9 g, fu ling 15 g
Ye 2007	CHM periodic therapy	Basic formula: cang zhu 10 g, bai zhu 10 g, zhe bei mu 15 g, shi chang pu 15 g, dan shen 10 g, xiang fu 10 g. Menstrual phase: basic formula plus tao ren 10 g, san qi 10 g, yi mu cao 15 g, for 3 to 5 days. Late follicular phase: basic formula plus tu si zi 15 g, dang gui 9 g, shi di 10 g, shan yu rou 10 g, fu ling 15 g, for 7 to 10 days. Ovulation phase: basic formula plus lu lu tong 20 g, e zhu 10 g, bei qi 20 g, gui zhi 9 g, for 3 days. Luteinising phase: basic formula plus tu si zi 15 g, dang gui 10 g, yin yang huo 10 g, rou gui 6 g, for 7 to 10 days.
Ma HX 2009	CHM formula	Basic formula in ethinyloestradiol cyproterone acetate therapy phase. Yin deficiency of liver and kidney: shu di 30 g, dang gui 15 g, bai shao 15 g, shan yu rou 15 g. Deficiency of spleen and kidney: shu di 30 g, ba ji 30 g, fried bai zhu 30 g, ren shen 15 g, raw huang qi 15 g, shan yu rou 9 g, gou qi zi 6 g, chai hu 1.5 g. Periodic formula Gui shao di huang soup at day 5 to 14 of menstrual cycle: dang gui 10 g, bai shao 15 g, shu di 15 g, shan yu rou 10 g, shan yao 10 g, fu ling 15 g, dan pi 10 g, ze xie 15 g. Tao hong si wu soup at day 12 to 16 of menstrual cycle: shu di 10 g, dang gui 15 g, chi shao 15 g, chuan xiong 10 g, tao ren 10 g, hong hua 10 g. Shou tao pellet after ovulation: tu si zi 20 g, sang ji sheng 15 g, e jiao 10 g, xu duan.
Li Y 2012	Compound Xuanju capsule	Ingredients: hei ma yi, yin yang huo, gou qi zi, she chuang zi (patent medicine, detailed prescription is not open)
Ainehchi 2019	Herbal mixture capsule	The powders were mixed with 5 (250 mg): 4 (200 mg): 3 (150 mg): 2 (100 mg) weight ratios of spearmint, ginger, cinnamon, and C. sinensis, respectively. Finally, obtained powder was used for preparation of 700 mg capsules.
Jin F 2016	CHM formula	bu shen huo xue yang mo decoction：shu di 20g, tu si zi 10g, dan shen 12g,chi shao 10g, xiang fu 10g, zi he che 10g, chuan xiong 10g, shan zhu yu 10g, dang gui 10g, chuan xu duan 10g, gou qi zi 10g, lu jiao jiao 10g, niu xi 10g.
Liang YM 2017	CHM formula	bu shen huo xue decoction: lu jiao shuang 15g, yu jin 10g, sang ji sheng 10g, dan shen 15g, ji xue teng 10g, gan cao 5g, tu si zi 10g, bu gu zhi 10g, san qi 5g, rou cong rong 10g, bai shu 10g, cang shu 10g, ze lan 10g, ze xie 10g.