Table 2.

Population characteristics

Reference study	Sample size N	Mean age, Years (SD)	FemaleN (%)	BD type 1 N (%)	Clinical state	Depression score at baseline (SD)	Manic score at baseline (SD)
Til et al. (2020)	47	41.9 (10.8)	25 (53.1)	32 (68.0)	NS	NS	NS
Faurholt-Jepsen et al. (2020)	85	43.0 (12.4)	52 (61.2)	54 (63.5)	NS	NS	NS
Depp et al. (2015)	41	46.9 (11.8)	22 (53.7)	36 (87.8)	Euthymic	MADRS: 11.7 (Moore et al. 2016)	YMRS: 7.4 (Myin-Germeys et al. 2016)
Stanislaus et al. (2020)	203	28.0 [24-35] *	140 (69.0)	68 (33.5)	NS	HAMD17: 9 [5-15] †	YMRS: 2 [0-7]a
Hidalgo-Mazzei et al. (2018)	201	36.6 (Firth et al. 2016)	127 (63.2)	NS	NS	NS	NS
Tsanas et al. (2016)	48	38.0 (Ng et al. 2019)	32 (66.7)	NS	NS	NS	NS
Schwartz et al. (2016)	10	48.9 (16.8)	7 (70.0)	10 (100)	Any mood state	NS	NS
Wenze et al. (2016)	8	44.0 (11.6)	5 (62.5)	5 (62.5)	At least moderate depression or mania	QIDS-C 15.2 (3.2)	CARS-M 7.2 (4.3)
Hidalgo-Mazzei et al. (2016)	51	43.9 (11.4)	21 (42.9)	33 (67.3)	Euthymic	HAMD-17: 3.2	YMRS: 2.1 (2.6)
Beiwinkel et al. (2016)	13	47.2 (3.8)	5 (38.5)	6 (46.1)	NS	NS	NS
Faurholt-Jepsen et al. (2015)	33	29.1 (7.4)	23 (71.0)	20 (60.6)	Euthymic	HAMD: 9 [4-16]a	YMRS: 2 [0–7]
Wenze et al. (2014)	14	40.9 (12.1)	10 (71.4)	5 (35.7)	NS	QIDS: 12.5 (4.0)	CARS-M: 9.9 (8.7)
Faurholt-Jepsen et al. (2014)	17	33.4 (9.5)	12 (70.6)	14 (82.4)	NS	NS	NS

BD Bipolar disorder, SD Standard deviation, NS Not specified, MADRS Montgomery and asberg depression scale, YMRS Young mania rating scale, HAMD17 Hamilton depression rating scale with 17 items version, HAMD Hamilton depression rating scale, QIDS-C Quick inventory of depressive symptomatology-Clinician Rating, QIDS-C Quick inventory of depressive symptomatology, CARS-M Clinician administered mania rating scale

^aMedian [interquartile range]