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. 2021 Jun 3;11:11707. doi: 10.1038/s41598-021-91070-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of Co²⁺, Cu²⁺ and Mg²⁺ ions on THP-1 cell proliferation. DNA quantification of THP-1 cells cultured with different Co²⁺, Cu²⁺ and Mg²⁺ concentrations for 24 and 48 h. The results of DNA quantification were compared to the TCP of each day and a statistically significant (p < 0.05) decrease was observed in some concentrations of Co²⁺ and Cu²⁺. Statistically significant differences (p < 0.05) were represented with *.