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. 2021 Jun 3;4:672. doi: 10.1038/s42003-021-02225-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — MC38 (a) or B16 (b) tumor cells were injected to WT or PAG KO mice. On day 5, 8, and 11 anti-PD-1 Abs (200 µg) were administered. Daily tumor growth as calculated from measurement by digital caliper. MC38 8–12 mice per group. B16 6–8 mice per group. aii, bii. Tumor volume on day 23 and day 21 of post-tumor implant, respectively, for mice that survived until the final day of the study. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001; ns not significant.