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. 2021 Jun 3;11:11804. doi: 10.1038/s41598-021-91097-3

Table 3.

Roughness correlations.

All subjects
NFL GCL IPL INL OPL ONL IS/OS OSL OPR RPE Total retina MMSE Visual acuity Age
NFL 0.43 0.49 0.43 0.24 0.50 0.40 0.19 0.19 0.41 0.25 −0.35 −0.45 0.38
GCL 0.42 0.38 0.54 0.49 0.49 0.17 0.16 0.11 0.32 0.35 0.05 −0.26 0.26
IPL 0.59 0.41 0.74 0.54 0.52 0.61 0.35 0.26 0.59 0.31 -0.05 -0.19 0.28
INL 0.49 0.62 0.74 0.48 0.40 0.41 0.15 0.12 0.56 0.55 -0.07 -0.18 0.26
OPL 0.32 0.52 0.60 0.47 0.61 0.34 0.29 0.37 0.26 0.07 0.08 0.07 0.02
ONL 0.48 0.49 0.69 0.34 0.58 0.30 0.32 0.43 0.43 -0.03 0.00 −0.29 0.13
IS/OS 0.63 0.09 0.67 0.39 0.18 0.47 0.29 0.29 0.62 0.31 0.02 -0.24 0.16
OSL 0.24 0.14 0.28 0.06 0.30 0.42 0.13 0.75 0.17 -0.08 0.14 0.08 0.13
OPR 0.27 0.13 0.26 0.03 0.32 0.41 0.24 0.89 0.22 -0.02 0.12 -0.04 0.01
RPE 0.41 0.35 0.58 0.61 0.16 0.36 0.66 0.12 0.03 0.40 -0.18 −0.35 0.23
Total retina 0.58 0.45 0.51 0.76 0.07 0.04 0.32 0.09 -0.08 0.56 0.01 0.03 0.17
MMSE 0.08 0.34 0.18 0.13 0.34 0.30 0.17 0.27 0.37 0.04 -0.04 0.34 0.43
Visual acuity 0.37 -0.34 -0.28 -0.17 0.10 −0.45 −0.54 -0.01 0.12 −0.57 -0.13 -0.03 0.32
Age 0.10 0.22 0.26 0.29 0.00 0.04 0.03 0.24 0.13 0.01 0.37 0.12 0.09
Alzheimer’s disease group

Mutual correlations of layer roughness and Alzheimer’s disease-related variables for the whole sample (upper triangular matrix) and for the Alzheimer’s disease group (lower triangular matrix). Statistically significant values appear in boldface or bold italics (p < 0.05). Correlations of the 10 retinal layers with non-retinal variables appear in italics.

NFL  nerve fiber layer, GCL ganglion cell layer, IPL inner plexiform layer, INL inner nuclear layer, OPL outer plexiform layer, ONL outer nuclear layer, IS/OS  inner segment/outer segment layer, OSL outer segment layer, OPR  outer segment PR/RPE complex, RPE retinal pigment epithelium, MMSE Mini-Mental State Examination.