Table 2.
Multivariate Cox analysis ITT.
| Progression-free survival | Overall survival | ||||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | p-value | HR | 95% CI | p- value | ||
| MRD status: neg versus pos | 0.39 | (0.31–0.48) | <0.001 | MRD status: neg versus pos | 0.41 | (0.30–0.56) | <0.001 |
| FISH: High versus Standard | 1.57 | (1.29–1.92) | <0.001 | FISH: High versus Standard | 2.29 | (1.79–2.95) | <0.001 |
| ISS: II versus I | 1.29 | (1.08–1.54) | 0.006 | ISS: II versus I | 1.61 | (1.24–2.08) | <0.001 |
| ISS: III versus I | 1.72 | (1.39–2.12) | <0.001 | ISS: III versus I | 2.32 | (1.74–3.08) | <0.001 |
| LDH: > ULN versus ≤ULN | 1.39 | (1.10–1.75) | 0.005 | LDH: > ULN versus ≤ULN | 1.82 | (1.37–2.42) | <0.001 |
| Age: ≥60 versus <60 | 0.97 | (0.83–1.14) | 0.741 | Age: ≥60 versus <60 | 1.04 | (0.84–1.30) | 0.696 |
Adjusted for sex.
MRD minimal residual disease, FISH fluorescence in situ hybridization, ISS International Staging System, LDH lactate dehydrogenase, ULN upper limit of normal, ITT intention to treat.