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. 2021 May 21;8:660246. doi: 10.3389/fcvm.2021.660246

Figure 2.

Figure 2

Middle pressure overload significantly impaired heart function, while mild pressure overload did not. (A,B) Representative M-mode echocardiographic and aortic arch images of mice in the sham, 7dp1d TAC, and 14dp1d TAC groups with 30G and 32G constriction. (C) Representative images of M-mode echocardiograph and aortic arch in sham and 21 days post 1 day TAC (21dp1d TAC) groups with 30G constriction. (D) Color Doppler mode images of aortic arch blood flow in sham and TAC groups after 7 days of surgery. The arrow points to the turbulent blood flow area. (E–I) Ejection fraction (EF), fractional shortening (FS), left ventricular end-diastolic dimension (LVEDD), left ventricular end-systolic dimension (LVESD), and corrected left ventricular mass (Corr.LV mass) were assessed by echocardiography; n = 7, 7dp1d sham; n = 11, 7dp1d 30G TAC; n = 10, 7dp1d 32G TAC; n = 7, 14dp1d sham; n = 8, 14dp1d 30G TAC; n = 8, 14dp1d 32G TAC; n = 7, 21dp1d sham; n = 7, 21dp1d 30G TAC. Data are presented as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001. Statistical significance was calculated using the unpaired two-tailed t-test.