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. 2021 Jun 3;12:3319. doi: 10.1038/s41467-021-23642-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Volcano plots of the differential lncRNAs expression in undifferentiated BMMs and BMMs-derived osteoclasts. b Venn diagram representing the selection strategy for conserved lncRNAs. c PhastCons and PhyloP score of Nron. d Q-PCR analysis of Nron expression in eight types of C57BL/6 J mouse tissue, (n = 3/group). e Q-PCR analysis of Nron, Trap, and Ctsk gene expression levels during BMMs osteoclast differentiation, (n = 3 biologically independent experiments). f Q-PCR analysis of Nron expression in whole bone specimens (without bone marrow) from sham and ovariectomized (OVX) mice, (n = 6/group). g Q-PCR analysis of Nron expression in CTSK + osteoclasts isolated by microdissection from Sham and OVX mice, (n = 6/group). Significant differences between two groups were determined by unpaired Student’s t-test (two-tailed) and significant differences among multiple groups were determined by one-way ANOVA with Dunnett’s multiple comparisons test. Data are presented as the means ± s.e.m. Source data are provided as a Source Data file.