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. 2021 Jun 3;12:3319. doi: 10.1038/s41467-021-23642-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Representative μCT images showing the 3D bone structures of femurs from 6-month-old female WT littermates and Nron cTG mice, (similar results were obtained in all mice, n = 6/group). Scale bar: 1 mm (all panels). b μCT measurements of BV/TV and Tb.N in femurs from 6-month-old female WT littermates and Nron cTG mice, (n = 6/group). c Representative H&E staining images of femurs from 6-month-old female WT littermates and Nron cTG mice, (similar results were obtained in all mice, n = 6/group). Scale bar: 500 μm. d Histological measurements of BV/TV values in c, (n = 6/group). e Representative TRAP staining images of femurs from 6-month-old female WT littermates and Nron cTG mice, (similar results were obtained in all mice, n = 6/group). Scale bar: 500 μm (upper panels); 100 μm (lower panels). f Quantification of osteoclastic metrics Oc.N/B.Pm and Oc.S/BS in subepiphyseal region of femurs in e, (n = 6/group). g Serum CTX-I and TRAP5b levels of 6-month-old female WT littermates and Nron cTG mice analyzed by ELISA, (n = 6/group). Data are presented as the means ± s.e.m. Significant differences between two groups were determined by unpaired Student’s t-test (two-tailed). Source data are provided as a Source Data file.