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. 2021 Jun 3;4:682. doi: 10.1038/s42003-021-02220-z

Fig. 2. Some drugs currently used for anti-COVID-19 treatment are able to induce KSHV lytic reactivation.

Fig. 2

a The iSLK.219 cells were treated with a dose range of anti-COVID-19 drugs, Azithromycin and Nafamostat mesylate, with doxycycline (Dox, 0.1 µg/mL) induction for 72 h. The expression of RFP and GFP was detected using fluorescence microscopy. Error bars represent S.D. for 4 image fields per well, *p < 0.05; **p < 0.01 (vs the vehicle control). b The supernatants from iSLK.219 cells treated by Azithromycin or Nafamostat mesylate for 72 h (11.1 µM, respectively) in combination with Dox were collected to infect naive HEK293T cells, then GFP expression was detected using fluorescence microscopy.