TABLE 2.
49 potential target genes of WP therapy for RA.
| No. | Target | Symbol | Entrez ID | No. | Target | Symbol | Entrez ID |
|---|---|---|---|---|---|---|---|
| 1 | Progesterone receptor | PGR | 5,241 | 26 | Transcription factor p65 | RELA | 5,970 |
| 2 | Mineralocorticoid receptor | NR3C2 | 4,306 | 27 | Inhibitor of nuclear factor kappa-B kinase subunit beta | IKBKB | 3,551 |
| 3 | Tumor necrosis factor | TNFSF15 | 9,966 | 28 | RAC-alpha serine/threonine-protein kinase | AKT1 | 207 |
| 4 | Interleukin-6 | IL6 | 3,569 | 29 | Mitogen-activated protein kinase 8 | MAPK8 | 5,599 |
| 5 | Monocyte differentiation antigen CD14 | CD14 | 929 | 30 | Interstitial collagenase | MMP1 | 4,312 |
| 6 | Lipopolysaccharide-binding protein | LBP | 3,929 | 31 | Signal transducer and activator of transcription 1-alpha/beta | STAT1 | 6,772 |
| 7 | Prostaglandin G/H synthase 1 | PTGS1 | 5,742 | 32 | Heme oxygenase 1 | HMOX1 | 3,162 |
| 8 | Prostaglandin G/H synthase 2 | PTGS2 | 5,743 | 33 | Cytochrome P450 3A4 | CYP3A4 | 1,576 |
| 9 | Muscarinic acetylcholine receptor M3 | CHRM3 | 1,131 | 34 | Cytochrome P450 1A2 | CYP1A2 | 1,544 |
| 10 | Muscarinic acetylcholine receptor M2 | CHRM2 | 1,129 | 35 | Cytochrome P450 1A1 | CYP1A1 | 1,543 |
| 11 | Beta-2 adrenergic receptor | ADRB2 | 154 | 36 | Intercellular adhesion molecule 1 | ICAM1 | 3,383 |
| 12 | Sodium-dependent serotonin transporter | SLC6A4 | 6,532 | 37 | E-selectin | SELE | 6,401 |
| 13 | Mu-type opioid receptor | OPRM1 | 4,988 | 38 | Vascular cell adhesion protein 1 | VCAM1 | 7,412 |
| 14 | Apoptosis regulator Bcl-2 | BCL2 | 596 | 39 | Nuclear receptor subfamily 1 group I member 2 | NR1I2 | 8,856 |
| 15 | Apoptosis regulator BAX | BAX | 581 | 40 | Arachidonate 5-lipoxygenase | ALOX5 | 240 |
| 16 | Caspase-9 | CASP9 | 842 | 41 | Hyaluronan synthase 2 | HAS2 | 3,037 |
| 17 | Transcription factor AP-1 | JUN | 3,725 | 42 | Glutathione S-transferase p | GSTP1 | 2,950 |
| 18 | Caspase-3 | CASP3 | 836 | 43 | Aryl hydrocarbon receptor | AHR | 196 |
| 19 | Caspase-8 | CASP8 | 841 | 44 | Nuclear receptor subfamily 1 group I member 3 | NR1I3 | 9,970 |
| 20 | Protein kinase C alpha type | PRKCA | 5,578 | 45 | Insulin receptor | INSR | 3,643 |
| 21 | Serum paraoxonase/arylesterase | PON1 | 5,444 | 46 | Glutathione S-transferase Mu 1 | GSTM1 | 2,944 |
| 22 | Nitric oxide synthase, inducible | NOS2 | 4,843 | 47 | Antileukoproteinase | SLPI | 6,590 |
| 23 | Androgen receptor | AR | 367 | 48 | Estrogen receptor | ESR1 | 2099 |
| 24 | Peroxisome proliferator- activated receptor gamma | PPARG | 5,468 | 49 | Catalase | CAT | 847 |
| 25 | Acetylcholinesterase | ACHE | 43 |