TABLE 5.

Multiple linear regression analysis to determine the individual factors that influence AT and NT AUC in healthy volunteers.

	Amitriptyline AUCinf (all factors: r = 0.66, r 2 = 0.43)		Nortriptyline AUC48h (all factors: r = 0.76, r 2 = 0.58)
Individual factors	Coefficient	p-value	Coefficient	p-value
Sex	−42.5	0.10	4.58	0.74
Age (years)	−1.13	0.59	−1.39	0.23
Body mass index (kg/m2)	1.65	0.78	−4.11	0.21
Glomerular filtration rate (ml/min/1.73 m2)	1.02	0.28	−0.02	0.97
OCT1 activity	10.40	0.45	11.56	0.14
CYP2C19 activity	−25.29	0.18	35.94	0.001
CYP2D6 activity	−53.07	0.002	−30.94	0.001