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Models of type IV system functions highlighting questions that remain to be answered. (A) IV-A RNP complexes likely bind DNA targets and recruit CasDinG for target unwinding and degradation. (B) IV-B RNP complexes likely interact with CasCysH to perform an unknown function. (C) The putative IV-C RNP complex likely binds a nucleic acid target and cleaves that target with the HD nuclease domain. Created with BioRender.com.
