Table 2.
An overview of vaccines produced using various yeast models
| S. No | Yeast model | Virus | Vaccine | Reference |
|---|---|---|---|---|
| 1 | Saccharomyces cerevisiae | Coxsackie virus |
VLP P1 and 3CD |
Zhao et al. 2013 |
|
VLP ChiEV-A71 |
Zhao et al. 2015 | |||
| Dengue virus |
PP Envelope domain III (scEDIII) |
Nguyen et al. 2013 | ||
| Enterovirus 71 |
VLP EV71 structural protein |
Li et al. 2013 | ||
|
VLP ChiEV-A71 |
Zhao et al. 2015 | |||
| Hepatitis B virus |
PP Hepatitis B surface antigen |
Jacobs et al. 1989 | ||
|
VLP HBsAg |
Pleckaityte et al. 2015 | |||
| Hepatitis C virus |
WRY NS3-Core fusion protein |
Haller et al. 2007 | ||
| HIV-1 |
YSD Envelope (Env) glycoprotein |
Wang et al. 2018 | ||
| Japanese encephalitis virus |
YSD Envelope protein (mannoprotein) |
Upadhyaya and Manjunath 2009 | ||
| New castle disease virus |
PP Hemagglutinin-neuraminidase |
Khulape et al. 2015 | ||
| Papillomavirus |
PP L1 protein |
Park et al. 2008 | ||
|
VLP Capsid proteins L1 or L1 plus L2 |
Lowe et al. 1997 | |||
|
PP Recombinant capsid protein |
Kim et al. 2014 | |||
| Parvovirus B19 |
VLP VP1 and VP2 |
Penkert et al. 2017 | ||
| Polyoma virus |
YCP VP1, a major capsid protein |
Tipper and Szomolanyi-Tsuda 2016 | ||
| Porcine circovirus type 2 |
VLP Capsid protein |
Chen et al. 2018 | ||
|
Red-spotted grouper NNV (RGNNV)/Nervous necrosis |
WRY Capsid protein |
Nguyet et al. 2013 | ||
| 2 | Pichia pastoris | Avian influenza virus |
PP Influenza A/H5N1 Neuraminidase |
Yongkiettrakul et al. 2009 |
| Avian leucosis virus |
PP ALV-J gp85 protein |
Jing et al. 2018 | ||
| Bursal disease virus (IBDV) |
PP VP2 gene of the Edgar strain of IBDV, hypervariable region of the VP2 gene (hvVP2) |
Villegas et al. 2008 | ||
| Chikungunia virus |
VLP Structural polyprotein |
Saraswat et al. 2016 | ||
| Classical swine fever virus |
PP Glycoprotein E2 |
Cheng et al. 2014 | ||
| Coxsackie virus A |
VLP P1 and 3CD proteins of CA6 |
Zhou et al. 2016 | ||
|
VLP P1 and 3CD proteins of CA16 |
Zhang et al. 2016a | |||
| Dengue virus |
VLP Envelope Glycoprotein |
Khetarpal et al. 2017 | ||
|
VLP Envelope protein domain III (EDIII) |
Ramasamy et al. 2018 | |||
|
VLP Envelope protein (E1-E4) |
Rajpoot et al. 2018 | |||
| Hepatitis B virus |
PP Recombinant hepatitis B surface antigen |
Hardy et al. 2000 | ||
| Hepatitis C virus |
PP Core E1E2 protein |
Fazlalipour et al. 2015 | ||
|
VLP Core protein (HCcAg) |
Acosta-Rivero et al. 2001 | |||
| Human papillomavirus |
VLP L1 proteins (16L1 and 18L1) |
Gupta et al. 2017 | ||
|
PP HPV type 16 L1-L2 Chimeric SAF protein |
Bredell et al. 2018 | |||
| Influenza virus |
PP Hemagglutinin (HA) protein |
Wang et al. 2019 | ||
|
YSD Alpha agglutinin |
Wasilenko et al. 2010 | |||
|
PP H5 haemagglutinin |
Pietrzak et al. 2016 | |||
| Norovirus |
VLP recombinant capsid protein |
Xia et al. 2007 | ||
| SARS-CoV |
PP Recombinant receptor binding domain of Spike protein |
Chen et al. 2020 | ||
| SARS-CoV-2 |
PP Recombinant receptor binding protein |
Pollet et al. 2020 | ||
| 3 | Hansenula polymorpha | Bovine viral diarrhoea virus |
VLP Chimera of membrane integral small surface protein (dS) of the duck hepatitis B virus fused with E2-BVDV |
Wetzel et al. 2018 |
| Classical swine fever virus |
VLP Chimera of membrane integral small surface protein (dS) of the duck hepatitis B virus fused with E2-CFSV |
Wetzel et al. 2018 | ||
| Feline leukemia virus |
VLP Chimera of membrane integral small surface protein (dS) of the duck hepatitis B virus fused with FeLVenv |
Wetzel et al. 2018 | ||
| West nile virus |
VLP Chimera of membrane integral small surface protein (dS) of the duck hepatitis B virus fused with WNVE |
Wetzel et al. 2018 | ||
| Hepatitis B virus |
PP VrHB-IB |
Caetano et al. 2017 | ||
|
PP Recombinant HBsAg |
Caetano et al. 2017 | |||
| Human Papillomavirus |
VLP Type 52 L1 Protein |
Liu et al. 2015 | ||
| Porcine circovirus type 2b |
VLP NLS-deleted capsid protein (ΔCP) |
Xiao et al. 2018 | ||
| 4 | Schizosaccharomyces pombe | Human papillomavirus type 6 & 16 |
VLP Capsid protein |
Sasagawa et al. 1995 |
| 5 | Kluyveromyces marxianus | Porcine circovirus type 2 |
VLP Capsid protein |
Duan et al. 2019 |
| 6 | Yarrowia lipolytica | Red spotted grouper Nervous necrosis virus |
VLP Capsid protein |
Luu et al. 2017 |
The table lists various yeast models such as S. cerevisiae, P. pastoris, H. polymorpha, K. lactis, S. pombe extensively used for the expression and production of vaccines. PP purified protein, VLP virus-like particle, WRY whole recombinant yeast, YSD yeast surface display