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. 2021 May 21;11:645979. doi: 10.3389/fonc.2021.645979

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Copyright © 2021 Chen, Qin, Li, Wo and Chen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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High HOXA13 expression is associated with 5-FU resistance. (A) qRT-PCR analysis of HOXA13 and ABCC4 expression in GC tissues compared with paired normal tissues. (B) Western blot analysis of HOXA13 and ABCC4 expression in GC tissues compared with paired normal tissues. (C) The Kaplan–Meier plotter showed that upregulation of HOXA13 was significantly associated with lower OS and PPS in GC patients with 5-FU treatment. (D) In 5-FU based chemotherapy, GC patients with high ABCC4 expression had poorer prognosis (http://kmplot.com/analysis/).