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. 2021 May 21;11:645979. doi: 10.3389/fonc.2021.645979

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Copyright © 2021 Chen, Qin, Li, Wo and Chen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HOXA13 upregulates ABCC4 expression via binding to its promoter region. (A) Volcano plot showed significantly upregulated genes in AGS-HOXA13 + 5-FU relative to AGS-Vector + 5-FU. (B) Pathway analysis revealed that ABC transporter pathway was significantly enriched. (C) Heatmap showed that ABCC4 was obviously upregulated in ABC transporter family. (D) The protein expression levels of ABCC4 in the indicated cell lines with altered HOXA13 expression. (E) Pearson’s correlation analysis of the mRNA levels of HOXA13 and ABCC4 in GC samples. (F) HOXA13 binding to the ABCC4 promoter region was predicted by JASPAR (http://jaspar.genereg.net/). (G) The results of ChIP assay and agarose gel electrophoresis indicated HOXA13 enriched in primer 1 within the ABCC4 promoter.