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. 2021 May 21;11:616625. doi: 10.3389/fonc.2021.616625

Figure 1.

Figure 1

Histological studies of androgen receptor (AR) expression in human brain/GBM tissue. (A–C) H&E staining of a GBM slide from a male patient (40×, 100× and 400× magnification, respectively). (D–F) Positive AR expression (brown) in a GBM slide from the same patient as A (40×, 100× and 400× magnification, respectively). (G–I) H&E staining of a GBM slide from a female patient (40×, 100× and 400× magnification, respectively). (J–L) AR staining in a GBM slide from the same patient as G (40×, 100× and 400× magnification, respectively). Enriched AR positive cells at peri-vascular area are best shown in K (arrow). Majority of AR staining (brown) is in nuclei in a subset of the cells (arrow in L). (M) H&E staining of a GBM specimen showing the endothelial proliferation of the vessels (arrow). (P) AR staining of the GBM specimen from the same patient as M. (N) H&E staining of a normal human brain autopsy specimen. (Q) Negative AR staining of the normal brain autopsy specimen from the same patient as N, at 400× magnification. (O) H&E staining and (R) scattered weakly positive nuclear staining of AR in a temporal lobectomy surgical specimen from a patient with epilepsy, at 400× magnification.