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. 2021 May 21;11:609548. doi: 10.3389/fonc.2021.609548

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Copyright © 2021 Li, He, Ye, Ye, He, Chen and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of p62, LC3B and Beclin 1 in bone metastasis tissues of lung adenocarcinoma. (A, B) Both p62 mRNA and protein expression levels were higher in tumor tissues (T) than in normal cancellous bone tissues (N). (C) LC3B and (D) Beclin 1 protein expression levels were higher in tumor tissues (T) than in normal cancellous bone tissues (N). (E) Positive correlation between p62 protein expression and LC3B protein expression (P=0.005). T, bone metastasis tissues; N, normal cancellous bone tissues. ^*P < 0.05, ^**P < 0.01.