Table 2.
Univariate and multivariate analysis of clinicopathologic variables in relation to OS in patients with GC.
| Clinicopathological features | Univariate analysis | P-value | Multivariate analysis | P-value |
|---|---|---|---|---|
| Age | ||||
| <65.0 | Reference | Reference | <0.001 | |
| ≥65.0 | 1.78 (1.41, 2.25) | <0.001 | 1.60 (1.44, 1.79) | |
| Gender | ||||
| Male | Reference | |||
| Female | 0.85 (0.46, 1.62) | 0.182 | ||
| BMI (kg/m2) | ||||
| ≥18.5 | Reference | Reference | ||
| <18.5 | 1.69 (1.27, 2.13) | <0.001 | 1.54 (1.21, 1.80) | <0.001 |
| Tumor size (cm) | ||||
| <3.0 | Reference | Reference | ||
| ≥3.0 | 2.03 (1.50, 2.52) | <0.001 | 1.27 (0.76, 1.63) | 0.438 |
| Tumor differentiation | ||||
| Differentiated | Reference | Reference | ||
| Undifferentiated | 1.58 (1.32, 2.15) | <0.001 | 1.47 (1.13, 1.92) | 0.008 |
| Lauren Classification | ||||
| Intestinal-type | Reference | Reference | ||
| Diffused-type | 1.23 (1.05, 1.78) | 0.001 | 1.16 (1.01, 1.45) | 0.009 |
| Mixed | 1.04 (0.67, 1.51) | 0.871 | ||
| Lymphatic invasion | ||||
| Negative | Reference | Reference | ||
| Positive | 1.93 (1.42, 2.88) | <0.001 | 1.60 (1.32, 2.12) | 0.004 |
| Vascular invasion | ||||
| Negative | Reference | Reference | ||
| Positive | 1.70 (1.28, 2.21) | <0.001 | 1.55 (1.32, 1.83) | <0.001 |
| Perineural invasion | ||||
| Negative | Reference | Reference | ||
| Positive | 1.83 (1.49, 2.65) | <0.001 | 1.62 (1.43, 1.90) | 0.011 |
| Tumor location | ||||
| Upper | Reference | |||
| Middle /Lower | 0.85 (0.39, 1.61) | 0.230 | ||
| pTNM stage | ||||
| I | Reference | Reference | ||
| II | 2.14 (1.45, 2.67) | 0.001 | 1.83 (1.32, 2.28) | <0.001 |
| III | 5.47 (2.31, 8.41) | 0.007 | 3.22 (2.10, 4.19) | <0.001 |
| Adjuvant chemotherapy | ||||
| No | Reference | |||
| Yes | 0.79 (0.45, 1.48) | 0.173 | ||
| Serum albumin (mg/dL) | ||||
| <40 | Reference | Reference | ||
| ≥40 | 0.65 (0.52, 0.94) | 0.001 | 0.72 (0.56, 0.90) | <0.001 |
| Total cholesterol (mg/dL) | ||||
| >180 | Reference | Reference | ||
| ≤ 180 | 1.52 (1.14, 2.10) | 0.001 | 1.46 (1.10, 1.87) | <0.001 |
| Neutrophil: lymphocyte ratio | ||||
| ≤ 2.96 | Reference | Reference | ||
| >2.96 | 1.69 (1.28, 2.26) | 0.003 | 1.59 (1.23, 1.92) | <0.001 |
| Lymphocyte: monocyte ratio | ||||
| >4.44 | Reference | Reference | ||
| ≤ 4.44 | 1.78 (1.33, 2.32) | <0.001 | 1.71 (1.22, 2.01) | <0.001 |
| NPS | ||||
| 0 | Reference | Reference | ||
| 1 | 2.68 (1.45, 4.01) | 0.002 | 2.21 (1.27, 3.31) | <0.001 |
| 2 | 3.82 (1.89, 6.80) | <0.001 | 3.45 (1.43, 5.17) | <0.001 |
OS, overall survival; GC, gastric cancer; BMI, body mass index; NPS, naples prognostic score.