Table 6. Risk factors for mortality in patients with infective endocarditis.
| Variables | Univariable analysis | Multivariable analysis | |||||
|---|---|---|---|---|---|---|---|
| OR | 95% CI | p value | HR | 95% CI | p value | ||
| Age (years) | 1.08 | 1.06–1.11 | <0.001 | 1.04 | 1.01–1.07 | 0.009 | |
| Female sex | 1.51 | 0.89–2.57 | 0.125 | - | - | - | |
| Chronic kidney disease | 5.81 | 3.26–10.37 | <0.001 | 2.93 | 1.58–5.44 | 0.001 | |
| Staphylococcus aureus infection | 3.75 | 2.10–6.72 | <0.001 | 3.26 | 1.68–6.33 | <0.001 | |
| Fungal infection | 9.47 | 4.21–21.30 | <0.001 | 3.13 | 1.25–7.86 | 0.015 | |
| Multivalvular affection | 2.64 | 1.46–4.78 | 0.001 | 2.13 | 1.14–3.98 | 0.017 | |
| Prosthetic valve endocarditis | 2.97 | 1.73–5.09 | <0.001 | 2.67 | 1.40–5.07 | 0.003 | |
| Valve repair surgery vs. | |||||||
| Bioprosthetic valve replacement | 5.85 | 2.48–13.83 | <0.001 | 1.58 | 0.61–4.07 | 0.347 | |
| Mechanical valve replacement | 0.76 | 0.28–2.10 | 0.602 | 0.62 | 0.21–1.85 | 0.388 | |
Early outcomes are given as OR; long-term outcomes are given as HR.
CI = confidence interval; HR = hazard ratio; OR = odds ratio.