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. 2021 May 21;11:668424. doi: 10.3389/fonc.2021.668424

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Copyright © 2021 Cheng, Yu, He, Li, Xu, Xue, Shi, Chen, Li, Hong and Xiao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gene expression analysis in thyroid cancer cells treated with SS. (A) Heatmap of differentially expressed genes between the SS and control groups. (B) Pathway enrichment analysis showing the top 10 changed pathways after SS treatment. (C) Single-sample gene set enrichment analysis (ssGSEA) was used to obtain the enrichment score of the oxidative phosphorylation pathway. (D) Volcano plot of genes enriched in the oxidative phosphorylation pathway (OXPHOS). (E) Relative RNA expression of the top 10 genes enriched in OXPHOS was validated by qRT-PCR in KHM-5M cells. SS, sodium selenite. *P < 0.05; **P < 0.01.