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. 2021 Jun;191(6):1020–1035. doi: 10.1016/j.ajpath.2021.02.018

Figure 8.

Figure 8

Inhibition of canonical Wnt signaling increases extracellular matrix in primary human trabecular meshwork (HTM) cells. HTM 2180 (A), HTM71FOS (B), and 2019-017 (C) HTM cells were transfected with nontargeting (NT) siRNA/β-catenin siRNA. The cells were treated with 0.1% ethanol (EtOH) or 100 nmol/L dexamethasone (Dex) for 2 days, and conditioned medium (CM) as well as whole cell lysate (WCL) were harvested for Western immunoblotting. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) served as a loading control for WCL. FN, fibronectin.