Table 3.
SF-36 and EORTC scores at baseline and cycle 24
| Treatment-naïve patients |
Relapsed/refractory patients |
Repeated measures ANOVA |
||||||
|---|---|---|---|---|---|---|---|---|
| Baseline | Cycle 24 | Baseline | Cycle 24 | Time | Cohort | |||
| Outcome | Mean (SE) | Mean (SE) | Mean (SE) | Mean (SE) | F | P | F | P |
| SF-36 | ||||||||
| PCS | 43.73 (2.39) | 48.70 (1.83) | 42.16 (2.85) | 46.98 (2.18) | 8.01 | 0.01 | 0.34 | 0.56 |
| MCS | 52.61 (2.21) | 53.02 (2.15) | 49.02 (2.64) | 50.37 (2.57) | 0.80 | 0.38 | 0.93 | 0.34 |
| EORTC | ||||||||
| Global health | 71.67 (4.73) | 78.33 (4.30) | 70.24 (5.65) | 77.98 (5.13) | 5.04 | 0.03 | 0.02 | 0.88 |
| EORTC symptom domainsa | ||||||||
| Financial difficulties | 10.00 (5.17) | 6.67 (4.35) | 11.91 (6.18) | 4.76 (5.20) | 0.86 | 0.36 | 0.00 | 1.00 |
| Diarrhea | 10.00 (4.49) | 5.00 (3.30) | 19.05 (5.37) | 4.76 (3.94) | 7.36 | 0.01 | 0.77 | 0.39 |
| Constipation | 3.33 (3.27) | 3.33 (4.43) | 7.14 (3.91) | 16.67 (5.29) | 1.67 | 0.21 | 3.16 | 0.09 |
| Appetite loss | 5.00 (3.22) | 5.00 (2.72) | 14.29 (3.85) | 4.76 (3.25) | 4.43 | 0.04 | 1.24 | 0.27 |
| Insomnia | 31.58 (7.18) | 19.30 (6.78) | 26.19 (8.36) | 28.57 (7.90) | 0.70 | 0.41 | 0.05 | 0.83 |
| Dyspnea | 8.33 (3.99) | 3.33 (2.69) | 19.05 (4.77) | 7.14 (3.21) | 6.94 | 0.01 | 2.96 | 0.10 |
| Pain | 22.50 (5.69) | 20.00 (5.23) | 16.67 (6.80) | 19.05 (6.27) | 0.00 | 0.99 | 0.20 | 0.66 |
| Nausea/vomiting | 1.67 (1.70) | 3.33 (1.55) | 4.76 (2.03) | 3.57 (1.86) | 0.05 | 0.83 | 0.54 | 0.47 |
| Fatigue | 26.67 (5.27) | 25.00 (4.19) | 32.54 (6.29) | 26.19 (5.01) | 0.82 | 0.37 | 0.35 | 0.56 |
| EORTC functional domainsb | ||||||||
| Social functioning | 90.00 (3.73) | 92.50 (2.97) | 89.29 (4.46) | 92.86 (3.56) | 0.95 | 0.34 | 0.00 | 0.97 |
| Cognitive functioning | 86.67 (3.78) | 83.33 (5.15) | 80.95 (4.52) | 77.38 (6.16) | 1.64 | 0.21 | 0.80 | 0.38 |
| Emotional functioning | 87.92 (3.86) | 87.92 (3.74) | 85.12 (4.61) | 83.33 (4.47) | 0.15 | 0.70 | 0.46 | 0.50 |
| Role functioning | 85.00 (5.18) | 87.50 (4.23) | 83.33 (6.19) | 91.67 (5.06) | 3.09 | 0.09 | 0.04 | 0.85 |
| Physical functioning | 92.83 (3.47) | 96.67 (2.13) | 83.81 (4.15) | 93.33 (2.54) | 7.50 | 0.01 | 2.69 | 0.11 |
Note: Significant time effects are noted in bold text.
Abbreviations: F, variation between sample means divided by the variation within samples; MCS, mental component score; PCS, physical component score.
a
Score range 0–100, with a higher score indicative of a higher level of symptoms. Correction for 9 multiple comparisons is P = 0.006.
b
Score range 0–100, with a higher score indicative of a higher level of functioning. Correction for 5 multiple comparisons is P = 0.01.