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. 2021 Apr 28;18(12):2561–2569. doi: 10.7150/ijms.56630

Figure 5.

Figure 5

Elucidation of SARS-CoV-2-induced genes whose expression was negatively correlated with IFNB1 expression in vitro. A. Pearson correlation coefficient-based analysis of genes whose expression was negatively correlated with IFNB1 expression. The expression of 15 genes was negatively correlated with that of IFNB1: EPSTI1, HELZ2, SOCS3, BST2, P2RY6, XAF1, GBP5, TNFSF14, TYMP, EDN1, MRGPRX3, MX2, CXCL1, PI3, and TNFAIP2. B. The results of KEGG analysis showed that the correlated genes were enriched in the TNF signaling pathway (SOCS3, CXCL1, and EDN1; adjusted p value=0.005464685 and gene count=3). C. The levels of genes enriched in the TNF signaling pathway upon SARS-CoV-2 infection in NHBEs. The FPKM values of the indicated genes were calculated and reflect the expression levels of these genes. The correlation coefficients (r) between IFNB1 and the corresponding genes are also indicated.