Figure 6.

Elucidation of SARS-CoV-2-induced genes whose expression was negatively correlated with IFNB1 expression in ferrets with SARS-CoV-2 infection. A. Based on the obtained Pearson correlation coefficients, the results of KEGG analysis revealed that genes that are negatively correlated with IFNB1 were primarily enriched in the phosphatidylinositol (PI) signaling system, circadian rhythm, and peroxisome pathways. B-D. Longitudinal changes in genes enriched in the signaling pathways shown in (A), the PI signaling system(B), circadian rhythm (C), and peroxisome (D) pathways, in SARS-CoV-2-infected ferrets. The levels of these genes are presented as FPKM values. The correlation coefficients (r) between IFNB1 and the corresponding genes are also indicated.