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. 2021 May 21;12:686320. doi: 10.3389/fgene.2021.686320

FIGURE 1.

FIGURE 1

Simplified graphic of the PICO-based queries employed at NCBI-PubMed. The search strategy was conducted as “((aging) AND (potential biomarker)) AND (biomarker)” for establishing the “c-score” and “((aging) AND (potential biomarker)) AND (biomarker),” filtered for reviews, for establishing the “rc-score.”