Skip to main content
. 2021 May 21;12:686320. doi: 10.3389/fgene.2021.686320

TABLE 1.

Frequently mentioned potential “routine laboratory” biomarkers.

Potential biomarkers Material Age linked processes# e-score rc-score* c-score
Lymphocytes/WBC [CDC] [PA] blood/EDTA Inflammation autoimmune disorders - 202 2240
Insulin blood/serum Diabetic state 148 1143
Glucose/glucose fastened [PA] blood/glucose monovette Diabetic state - 111 1175
C-reactive protein (CRP/hsCRP) [IA] [PA] blood/plasma Inflammation, cancer, cardiovascular disease - 71 1146
Cholesterol blood/plasma Cardiovascular disease - 67 896
Albumin [PA] blood/plasma Kidney and liver dysfunction - 65 1062
IL6 [IA] blood/plasma Inflammation - 58 979
Tumor necrosis factor alpha (TNFα) [IA] blood/serum Inflammation, cancer 51 751
Hemoglobin [CDC] blood/EDTA Anemia, other hematopoietic disorders - 39 471
Insulin-like growth factor 1 (IGF-1) blood/serum Metabolic disease 29 263
LDL-cholesterol blood/plasma Cardiovascular disease - 24 280
Triglycerides blood/plasma Cardiovascular disease - 23 498
HDL-cholesterol blood/plasma Cardiovascular disease - 23 349
Creatinine [PA] blood/plasma Kidney dysfunction - 19 479
Monocytes blood/EDTA Inflammation - 16 378
Glycated hemoglobin (Hba1c) blood/EDTA Diabetic state - 13 220
Cystatin C blood/plasma Kidney dysfunction - 12 142
N-terminal prohormone of brain natriuretic peptide (NT-proBNP) blood/EDTA Heart failure - 10 119
Alkaline phosphatase [PA] blood/plasma Liver damage, bone disorder - 9 252
Hematocrit/RBC [CDC] blood/EDTA Anemia - 8 159
D-dimer blood/citrate monovette Hypercoagulable state - 8 91
IL8 [IA] blood/plasma Inflammation 7 164
Plasminogen activator inhibitor-1 (PAI1) blood/EDTA Prothrombotic state in cancer and other acute phases 6 72
Bilirubin blood/plasma Liver dysfunction - 5 46
Urea blood/plasma Renal dysfunction - 3 137
IL15 blood/plasma Inflammation 3 55
Mean corpuscular volume/MCV [CDC] [PA] blood/EDTA Anemia, other hematopoietic disorders - 2 42
Mean corpuscular hemoglobin concentration/MCHC [CDC] blood/EDTA Anemia, other hematopoietic disorders - 2 32
CD4/CD8 ratio blood/EDTA Immune deficiency, autoimmunity 1 103
C-peptide (preferable to insulin) blood/serum Diabetic state - 1 32
IL1-β [IA] blood/plasma inflammation 1 5

* rows are sorted by rc-score. [IA] = inflammaging
# frequently mentioned general or disease-linked processes. [PA] = Phenotypic Age
[CDC] = complete blood count