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. 2021 May 21;12:686320. doi: 10.3389/fgene.2021.686320

TABLE 4.

Frequently mentioned potential non-blood physical capability and organ function biomarker.

Potential biomarkers Method Age linked processes# Domain e-score rc-score* c-score
Physical capability
Grip strength Physical exam Mortality, morbidity Strength 11 229
Walking speed Physical exam Mortality, morbidity Locomotor function 3 106
Standing balance Physical exam Mortality, morbidity Balance 1 26
Timed up and go test Physical exam Mortality, morbidity Locomotor function 0 11
Organ function
Atherosclerotic lesions IMT, ultrasound Mortality, CAD Cardiovascular system 158 680
Muscle mass MRI Mortality, cardiovascular risk Body composition 81 495
Systolic blood pressure Auscultatory method Mortality, cardiovascular risk Cardiovascular system 65 844
Cognitive function Various Mortality, morbidity Brain function 56 581
Body mass index Calculated Mortality CAD Body composition 24 1280
Bone density Bone density test Mortality, morbidity Body composition 17 84
Lung function Spirometry Mortality, morbidity Respiratory system 16 84
Waist circumference Tape measure Mortality, cardiovascular risk Body composition 3 202
General well being
Health assessments Questionnaire Mortality, morbidity General n.a. n.a.

* rows are sorted by c-score. # frequently mentioned general or disease-linked. n.a.: not assigned due to high variation of terminology in literature.