Fig. 1.

Imatinib increases LC3-II, beclin 1, and mature cathepsin D expression. Neonatal cultured cardiomyocytes were treated with imatinib (1-10 μmol/L) for 6 h. Representative expression of LC3-I and LC3-II (a, top panel), beclin 1 (b, top panel), and mature cathepsin D (c, top panel). Actin was used as a loading control. The expression levels of LC3-II (a, bottom panel), beclin 1 (b, bottom panel), and mature cathepsin D (c, bottom panel) were quantified and presented as bar graphs (n = 6-8). * p < 0.05 versus cont. LC3: microtubule-associated protein 1 light chain 3 protein.