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. 2021 May 5;12(13):3909–3919. doi: 10.7150/jca.55666

Figure 7.

Figure 7

The LINC01272/miR-876/ITGB2 axis regulated EMT and metastasis. a, HCT116 cells were transfected with si-LINC01272, si-ITGB2, miR-876 mimics and their corresponding controls. After culturing for 48 hours, RNA was extracted for qRT-PCR assay. The results showed that by inhibiting LINC01272 or ITGB2 expression, miR-876 overexpression inhibited the expression of EMT core factors, including VIM, E-cadherin, SLUG, TWIST and ZEB1. b, Schematic representation of a model depicting the major molecular mechanisms of the LINC01272/miR-876/ITGB2 axis in CRC.