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. 2021 May 13;12(13):4064–4074. doi: 10.7150/jca.56982

Table 2.

Univariate and multivariate analyses of distant metastasis-free survival in HCC patients (n = 232) by Cox regression analysis

Variables Univariate Analysis Multivariate analysis
HR (95% CI) P HR (95% CI) P
Gender 1.293 (0.624-2.676) 0.489
Age 1.332 (0.708-2.505) 0.373
Cirrhosis 0.784 (0.442-1.390) 0.405
HBV 0.696 (0.383-1.265) 0.234
HCV 0.747 (0.348-1.604) 0.455
AFP 1.583 (0.847-2.960) 0.150
Bilirubin 1.273 (0.592-2.739) 0.537
ALT 0.912 (0.511-1.628) 0.756
AST 1.123 (0.613-2.054) 0.708
Prothrombin time 0.827 (0.456-1.500) 0.531
Alcoholism 1.006 (0.512-1.977) 0.986
Tumor number 1.295 (1.013-1.655) 0.039 1.178 (0.932-1.489) 0.171
Tumor size 1.776 (0.998-3.162) 0.051
Grade 1.350 (0.896-2.034) 0.151
Microvascular invasion 2.837 (1.616-5.106) 0.000 2.711 (1.616-5.106) 0.001
Macrovascular invasion 2.716 (1.307-5.643) 0.007 3.360 (1.106-10.209) 0.033
γ-OHPdG (noncancerous tissue) 1.995 (1.099-3.622) 0.023 2.758 (1.104-6.889) 0.030
γ-OHPdG (tumor) 1.049 (0.592-1.859) 0.871

Abbreviations: HR: hazard ratio; CI: confidence interval.