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. 2021 May 5;12(13):3877–3886. doi: 10.7150/jca.52315

Figure 1.

Figure 1

VES induces phagocytosis of HeLa cancer cells by THP-1 macrophages. (A) After treatment of 10 µg/mL VES for 24 h, the HeLa cancer cells were co-cultured with THP-1 macrophages for 30, 60, 90, 120 min. Phagocytosis of the tumour cells by macrophages was evaluated via flow cytometry after the treatment of PE-conjugated anti-CD11c antibody. Phagocytic rate was the number of phagocytosed cancer cells in 100 THP-1 macrophages.*P ≤ 0.05 compared with control. (B) Microscope image of THP-1 macrophages that phagocytosed HeLa cancer cells. HeLa cancer cells loaded with CFSE (green fluorescence) were co-cultured with THP-1 macrophages for 60 min. Arrows, individual phagocytosed HeLa cancer cells. The data are representative of at least 3 independent experiments.