Table 4.
Subtypes | Cases | GATA1 | GATA2 | GATA3 | GATA4 | GATA5 | GATA6 | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | ||
Stage | |||||||||||||
1 | 325 | 1.26 (0.81-1.95) | 0.3 | 0.67 (0.43-1.05) | 0.076 | 1.01 (0.65-1.56) | 0.98 | 1.18 (0.76-1.83) | 0.46 | 0.79 (0.51-1.23) | 0.29 | 0.63 (0.41-0.98) | 0.04 |
2 | 130 | 1.39 (0.83-2.34) | 0.2 | 0.69 (0.41-1.17) | 0.16 | 1.23 (0.74-2.07) | 0.42 | 1.09 (0.65-1.83) | 0.74 | 1.02 (0.59-1.73) | 0.96 | 0.9 (0.53-1.5) | 0.68 |
3 | 19 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
4 | 0 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
Grade | |||||||||||||
I | 140 | 1.61 (1.04-2.51) | 0.033 | 1.05 (0.68-1.63) | 0.82 | 1.05 (0.68-1.62) | 0.83 | 0.97 (0.63-1.5) | 0.88 | NA | NA | 0.93 (0.6-1.44) | 0.76 |
II | 165 | 0.74 (0.49-1.13) | 0.16 | 0.7 (0.46-1.06) | 0.089 | 0.74 (0.49-1.13) | 0.16 | 1.15 (0.76-1.74) | 0.51 | NA | NA | 0.67 (0.44-1.02) | 0.061 |
III | 51 | 1.16 (0.52-2.59) | 0.71 | 1.5 (0.66-3.4) | 0.32 | 1.06 (0.47-2.36) | 0.89 | 1.77 (0.78-4.05) | 0.17 | NA | NA | 0.95 (0.43-2.12) | 0.9 |
Smoking history | |||||||||||||
Exclude those never smoked | 603 | 1.91 (1.49-2.44) | 2.4e-7 | 0.82 (0.64-1.04) | 0.11 | 0.62 (0.48-0.79) | 1.1e-4 | 1.45 (1.14-1.85) | 0.0027 | 1.09 (0.74-1.61) | 0.67 | 0.62 (0.48-0.79) | 0.0001 |
Only those never smoked | 193 | 1.8 (1.11-2.92) | 0.015 | 0.48 (0.29-0.79) | 0.003 | 0.63 (0.39-1.01) | 0.053 | 0.87 (0.54-1.41) | 0.58 | 0.59 (0.31-1.13) | 0.11 | 0.6 (0.37-0.97) | 0.037 |