Table 8.

Direct and indirect mediation results.

Measure			GIa symptom severity					IBSb quality of life
			Effect (95% BCIc)		P value		Effect (95% BCI)			P value
Visceral anxiety
	Indirect	–4.3 (–7.0 to –1.8)		.002		–12.2 (–18.62 to –6.4)			<.001
	Direct	–5.1 (–8.8 to –1.4)		.007		–4.6 (–9.8 to –.56)			.08
GI-specific catastrophizing
	Indirect	–3.7 (–7.1 to –1.2)		.007		–15.4 (–21.6 to –9.6)			<.001
	Direct	–5.6 (–10.2 to –1.1)		.02		–1.4 (–7.9 to 5.1)			.67
Fear of food
	Indirect	–4.0 (–7.2 to –1.5)		.003		–9.8 (–16.3 to –3.8)			<.001
	Direct	–5.4 (–9.1 to –1.6)		.005		–7.0 (–12.7 to –1.4)			.02
Parallel multiple mediator model
	Direct	–9.4 (–13.5 to –5.3)		<.001		–.5 (–5.2 to 4.2)			.83
	Visceral anxiety	–3.4 (–6.2 to –1.0)		N/Ad		–7.0 (–11.3 to –3.4)			N/A
	COGe	1.8 (–1.0 to 4.4)		N/A		–5.1 (–9.0 to –1.8)			N/A
	Fear of food	–2.7 (–5.5 to –0.8)		N/A		–4.3 (–8.3 to –1.2)			N/A

^aGI: gastrointestinal.

^bIBS: irritable bowel syndrome.

^cBCI: bias-corrected confidence interval.

^dN/A: not applicable.

^eCOG: cognition.