Fig. 5.
CAR-T cells efficiently eradicate PDX tumors. (A) Schema of experiments. On day −10, ESCC tumor tissues from 2 patients were transplanted into NSG mice at the back, respectively (6 mice/group). On day 0, a total of 2 × 106 CAR-T cells generated from healthy donors were injected through the tail vein. (B and C) CD276 expression in PDX tissues derived from 2 patients with ESCC. Scale bar, 50 μm. (D and E) Tumors were measured with a caliper and the volumes were calculated twice per week. (F and G) Mouse survival was recorded. Survival curves were compared by Log-rank test following Bonferroni correction. ***, P < 0.005.