Table 3. Age-Stratified Disease Frequency and Odds Ratios Among Carriers of the Heterozygous MYOC c.1102C>T, p.(Gln368Ter) Variant in Different Glaucoma Types in FinnGen Cohort.
| Age, y | Carriers, No. (%) | OR | P valuea |
|---|---|---|---|
| Glaucoma | |||
| <40 | 10 (4.7) | 3.34 (1.57-6.31) | .001 |
| <50 | 26 (6.7) | 3.17 (2.04-4.75) | <.001 |
| 50-59 | 17 (7.5) | 1.87 (1.07-3.08) | .02 |
| 60-65 | 21 (13.5) | 3.04 (1.82-4.86) | <.001 |
| >65 | 54 (11.7) | 2.60 (1.91-3.46) | <.001 |
| POAG | |||
| <40 | 1 (0.5) | 2.33 (0.06-13.49) | .35 |
| <50 | 9 (2.4) | 4.81 (2.16-9.35) | <.001 |
| 50-59 | 8 (3.7) | 2.59 (1.10-5.24) | .02 |
| 60-65 | 9 (6.3) | 3.21 (1.43-6.33) | .003 |
| >65 | 35 (7.9) | 3.55 (2.43-5.04) | <.001 |
| Suspected glaucoma | |||
| <40 | 10 (4.7) | 5.88 (2.75-11.7) | <.001 |
| <50 | 19 (5.0) | 3.77 (2.24-6.01) | <.001 |
| 50-59 | 8 (3.7) | 1.44 (0.61-2.89) | .28 |
| 60-65 | 9 (6.3) | 2.36 (1.05-4.64) | .02 |
| >65 | 28 (6.4) | 2.63 (1.72-3.87) | <.001 |
| Exfoliation glaucoma | |||
| <40 | 0 | NA | NA |
| <50 | 2 (0.6) | 5.90 (0.70-22.41) | .05 |
| 50-59 | 4 (1.9) | 5.96 (1.58-15.86) | .005 |
| 60-65 | 1 (0.7) | 0.92 (0.02-5.28) | >.99 |
| >65 | 14 (3.3) | 2.52 (1.36-4.3) | .002 |
Abbreviations: NA, not applicable; OR, odds ratio; POAG, primary open-angle glaucoma.
a
Fisher exact test, 2-tailed.