Table 4. Phenome-Wide Carrier Analysis Results for MYOC c.1102C>T, p.(Gln368Ter) in FinnGen for Different Glaucoma Types.
| Glaucoma type | No. | βa | OR (95% CI) | P value |
|---|---|---|---|---|
| Any | 8591 | 1.5 (0.18) | 4.62 (4.27-4.96) | 2.3E-18 |
| POAG | 3412 | 2.3 (0.29) | 9.92 (9.36-10.49) | 2.2E-15 |
| Suspected glaucoma | 4766 | 1.4 (0.23) | 4.19 (3.74-4.64) | 3.3E-10 |
| Exfoliation glaucoma | 1515 | 1.8 (0.43) | 5.83 (5.00-6.66) | 3.4E-5 |
| Glaucoma-related operations | 459 | 4.6 (0.88) | 94.90 (93.18-96.62) | 2.0E-7 |
| NTG | 892 | 0.72 (0.47) | 2.06 (1.13-2.98) | 1.3E-1 |
Abbreviations: NTG, normal-tension glaucoma; OR, odds ratio; POAG, primary open-angle glaucoma.
a
Estimated with SAIGE for the alternative allele.