Table 3. Validated Classification of Reasons for Treatment Nonadherence or Nonpersistence to Therapy in Neovascular Age-Related Macular Degeneration.

Classification	Subcategories	Mean (SD) Delphi score
Patient associated	Patient education level or understanding of the need for treatment Patient loss of motivation Ocular comorbidities Nonocular comorbidities or general health problems Consent withdrawal Treatment burden Other	9.27 (1.56)
Condition associated	Treatment success (patient determined) Treatment failure (patient determined) Treatment contraindication Poor baseline visual acuity Other	9.27 (1.42)
Therapy associated	Treatment discomfort Adverse event Fear of injections Other	8.64 (2.34)
Health system and health care team associated	Administrative problem Access to treatment (eg, appointment availability) Distance to treatment Other	8.73 (2.33)
Social/economic	Lack of transportation Caregiver availability (eg, to attend clinic appointment with patient) Direct cost or reimbursement issue Indirect costs (eg, parking fees, productivity loss) Other	8.82 (2.34)
Other	Death Uncontrollable/unpredictable event (eg, restrictions or deferral of appointment because of COVID-19 pandemic)	9.64 (0.67)