Table 3.
The accuracy of different HR-HPV genotyping models to triage women with HR-HPV positive and simultaneous LSIL to detect underlying CIN2+
| HR-HPV genotyping models | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Referral ratea (%) |
|---|---|---|---|---|---|
| HPV16/18b | 54.9 (48.1-61.4) | 79.6 (76.3-82.5) | 47.3 (41.2-53.6) | 84.1 (80.9-86.8) | 29.0 (262/902) |
| HPV16/18/58c | 70.8 (64.3-76.5) | 61.7 (57.9-65.3) | 38.2 (33.5-43.0) | 86.3 (82.9-89.2) | 46.5 (419/902) |
| HPV16/18/52/58d | 84.0 (78.5-88.5) | 40.8 (37.1-44.6) | 32.2 (28.5-36.2) | 88.5 (84.2-91.7) | 65.4 (590/902) |
| HPV16/18/33/52/58e | 89.4 (84.4-92.9) | 35.7 (32.1-39.4) | 31.7 (28.1-35.5) | 90.9 (88.7-94.0) | 70.6 (637/902) |
| HPV16/18/31/33/52/58f | 92.9 (88.5-95.8) | 31.4 (27.9-35.0) | 31.2 (27.7-34.8) | 93.0 (88.6-95.8) | 74.7 (674/902) |
Note: a: The rate of referred to colposcopy in LSIL women; b: Women with any infection of HPV-16, -18; c: Women with any infection of HPV-16, -18, -58; d: Women with any infection of HPV-16, -18, -52, -58; e: Women with any infection of HPV-16, -18, -33, -52, -58; f: Women with any infection of HPV-16, -18, -31, -33, -52, -58.
Abbreviations: HR-HPV, high-risk human papillomavirus; LSIL, low-grade squamous intraepithelial lesion; CIN2+, cervical intraepithelial neoplasia grade 2 or worse; PPV, positive predictive value; NPV, negative predictive value.