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. 2021 Jun 2;218(7):e20201354. doi: 10.1084/jem.20201354

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© 2021 Verma et al.

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Figure 3. — Effect of anti-CD90 antibody-mediated depletion of ILCs and duration of memory. (A) A timeline for anti-CD90.2 administration. (B–G) Effect of depletion ILCs by treatment with an anti-CD90 antibody (isotype antibody as a control) on airway hyperreactivity (B), lung eosinophils (C), ICOS⁺ST2⁺ ILC2s (D), IL5⁺ (E), IL13⁺ (F), and airway inflammation (G). BM, bone marrow. ***, P < 0.0001; **, P < 0.001; *, P < 0.01, unpaired t test in Rag1^−/− mice sensitized and challenged with Alt. (H–K) The duration of persistence of memory. Rag1^−/− mice were exposed to Alt as per Fig. 1 A and then had a recall (R) challenge with Alt in week (W) 6, 9, or 15 (labeled as 6, 9, or 15 W-R, respectively). A control group was exposed to Sal and challenged with Sal in week 15 (Sal/Sal). The mice had measurements of airway hyperreactivity (H; two-way ANOVA), lung eosinophils (I), CD45⁺CD25⁺ICOS⁺ST2⁺ ILCs (J), and IL13⁺ ILC2s (CD45⁺CD25⁺ICOS⁺ST2⁺; K) as described above. ***, P < 0.0001 versus Sal/Sal (one-way ANOVA, n = 3–5/group).